THE PKRRATING DIARIES

The activated enzyme then phosphorylates its significant substrate, the translational initiation variable eIF2α. The ensuing translational arrest blocks viral replication. PKR belongs to a conserved family of 4 protein kinases (PKR, PERK, GCN2, HRI) that all phosphorylate eIF2α in response to unique stimuli12, triggering the built-in anxiety resp